Non-random vs random selection for receptor clonotypes

By: James V. Kohl | Published on: February 13, 2019

High frequency of shared clonotypes in human B cell receptor repertoires
Reported as: Decoding the human immune system (2/13/19)

The receptors randomly select and join gene segments, forming unique sequences of nucleotides known as receptor “clonotypes.”

A nucleotide is composed of a five-carbon sugar, a nitrogenous base and a phosphate group. The unique sequences of nucleic a.cids (RNA and DNA) are made up of a series of nucleotides. The center of an amino acid is the carbon bonded to four different groups. The fourth group, R, is different for each amino acid.

I knew that light-activated microRNA biogenesis was linked to biophysically constrained viral latency and all biodiversity via the nucleic acid microRNA peptide nanocomplex and the physiology of reproduction.

See: Plant Extracellular Vesicles Contain Diverse Small RNA Species and Are Enriched in 10 to 17 Nucleotide “Tiny” RNAs and Items: 1 to 20 of 10249

So, I searched for the term.  receptor clonotype See 1 of 16 items:

Radiation leukemia virus-induced T-cell lymphomas with common T-cell receptor variable region structure and similar binding specificity for retrovirus (1991)

T-cell receptor clonotype may be targets for transformation by a particular retrovirus

The claim that a human endogenous retrovirus might cause non-random changes in the nucleotides and the so-called receptor clonotype was made 28 years ago and the term “receptor clonotype” was used 15 more times. For comparison, we linked energy-dependent non-random changes to cell type differentiation via alternative splicings of pre-mRNAs in 1996. The pre-mRNAs are now called microRNAs. See our section on molecular epigenetics in  From Fertilization to Adult Sexual Behavior

See for comparison: microRNA Search results Items: 1 to 20 of 83131

The Downregulation of MicroRNA hsa-miR-340-5p in IAV-Infected A549 Cells Suppresses Viral Replication by Targeting RIG-I and OAS2.

See also: microRNA retrovirus

Bovine leukemia virus pre-miRNA genes’ polymorphism Items: 1 to 20 of 894

The cure for cancer reported by researchers from Israel attests to the fact that the most recent report on “decoding the human immune system” with use of the outdated term receptor clonotype in the context of receptors randomly that somehow select and join gene segments is another attempt to obfuscate the facts about the light-activated non-random assembly of the nucleic acid microRNA peptide nanocomplex.

You and your loved ones will probably suffer unnecessarily and die prematurely because researchers are playing “word games” to prevent you from understanding claims about energy-dependent biophysically constrained viral latency and the prevention of all diseases. The latest insult to your intelligence helps to ensure you may never learn how the word games have been linked to all pathology during the past 54 years since McEwen et al., published:

Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)

The synthesis of RNA in isolated thymus nuclei is ATP dependent.
The energy-dependent creation of ATP and RNA has been linked from the creation of supercoiled DNA to biophysically constrained viral latency in all living genera via the physiology of reproduction.  Nothing known to any serious scientist about cell type differentiation has been placed back into this context: …receptors randomly select and join gene segments, forming unique sequences of nucleotides known as receptor “clonotypes.”
It is time to question the motives of biologically uninformed researchers who tout the pseudoscientific nonsense about receptors that randomly select for receptor clonotypes, and ask how their nonsense get past peer review for publication in “Nature.”

See also: Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors
Reported as: Human Breast Milk Microbiome Affected by Mode of Feeding

Until recently, breast milk was thought to be sterile, but it has since been found to harbor a low level of bacteria that may help establish the infant gut microbiome and possibly influence the development of conditions like asthma and obesity.


Notify of
Inline Feedbacks
View all comments

Want more on the same topic?

Swipe/Drag Left and Right To Browse Related Posts: