Blood music orchestrates human life (3)
(click to enlarge)
Potential Excessive Testing at Scale: Biomarkers, Genomics, and Machine LearningPotential Excessive Testing at Scale: Biomarkers, Genomics, and Machine LearningPotential Excessive Testing at Scale: Biomarkers, Genomics, and Machine Learning 1/8/19
One of two co-authors of this “viewpoint,” Kenneth D. Mandl wrote (with my emphasis):
Biomarkup—when biomarkers are promoted and sometimes even designed for economic gain. @arjunmanrai and I expect it to be a hallmark of genomic and AI-driven medicine. @JAMA_current https://bit.ly/2SEAB2o
Dr. Michael Joyner wrote (with my emphasis):
This is such an important paper – the incidentalome on steroids @zakkohane & what do your enthusiast colleagues @broad and MGH say? @cecilejanssens @VPrasadMDMPH @ACasadevall1 @sandrogalea @jflier
Previously, Joyner claimed that Precision medicine’s rosy predictions haven’t come true. We need fewer promises and more debate
Endless debate is common among theorists and biologically uninformed pseudoscientists. I was surprised to see Joyner claim we need more debate and then comment on the incidentalome. I had never heard a serious scientist mention the incidentalome in any context whatsoever.
I asked:
Does the ‘incidentalome’ link the National Microbiome Initiative to the Precision Medicine Initiative and the cure for all virus-driven pathology such as cancer (i.e., the light-activated assembly of the peptide nucleic acid-microRNA nanocomplex)?
For comparison, the light-activated assembly of the peptide nucleic acid-microRNA nanocomplex has been linked to: Epigenetic age is a cell-intrinsic property in transplanted human hematopoietic cells
The link was reported as: Blood cells could hold master clock behind aging (2/7/19)
The study showed blood cells retain epigenetic patterns in DNA methylation—chemical groups attached to DNA—that can be used to calculate their age.
…Matsuyama’s team is working to understand why epigenetic age differences exist in cancer cells, and how they could be overcome. “It may be by turning on or off certain genes within the cells, we can reset the clock.”
Recent studies show the DNA age of human cells can be used as a biomarker to predict the risk of age-associated diseases, such Alzheimer’s disease, cardiovascular disease, and others. Last year, Horvath and Matsuyama helped publish an article reporting that DNA age is significantly accelerated in Progeria patients who suffer from premature aging. Matsuyama and his colleagues now have several studies underway to uncover the mechanism of age-dependent DNA methylation, and to understand how factors such as diet, exercise, and oxygen levels influence epigenetic clocks.
What role does the so-called incidentalome play? Is it linked to the magic of evolution by coincidence in the context of the coincidentalome?
For comparison, McEwen et al., (1964) linked the creation of ATP and the creation of RNA to to the epigenetic clocks in Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”
The synthesis of RNA in isolated thymus nuclei is ATP dependent.
That’s not a coincidence. Clearly, many others have failed to move forward. Until more of them learn to link the creation of subatomic particles to the creation of ATP and the creation of RNA, which biophysically constrained viral latency, they cannot match what Bumbarger et al. (2013), did via their example of nutrient-dependent pheromone-controlled changes in C. elegans and sympatric speciation in a predatory nematode with teeth.
Pristionchus and other diplogastrid nematodes carry living bacteria in the gut, and they gain energy from organismic interactions during bacterial feeding
Reported as: The neurobiological consequence of predating or grazing
“The patterns of synaptic connections perfectly mirror the fundamental differences in the feeding behaviours of P. pacificus and C. elegans”, Ralf Sommer concludes.
The ClinVar database of reports of the relationships among human variations and phenotypes and the HbVar database of human Hemoglobin Variants and Thalassemia Mutations collectively link what people eat to more than 1700 human hemoglobin variants via the light activated assembly of the peptide nucleic acid-microRNA nanocomplex, which prevents all virus-driven pathology in the context of Biblical Genesis and the food energy-dependent pheromone-controlled physiology of reproduction.
For example, fixation of the EDAR V370A variant in the mouse-to-human model of ecological adaptations also links the creation of achiral glycine to all morphological and behavioral phenotypes in all vertebrates with jaws.
See also: Difference in mass resulting from the change of a single amino acid
As an example the change from Asp to His will increase the normal mass by 22 units and the reverse change will decrease the mass by the same amount.
See also: Olfaction Warps Visual Time Perception (2017)
The authors linked the creation of the sense of smell in bacteria to our visual perception of mass and energy in the context of the space-time continuum.
I don’t expect any answers to my question about the incindentalome in that context, or in the context of how microRNAs in circulating blood link the sun’s anti-entropic virucidal energy to biophysically constrained viral latency in all living genera via the food that organisms eat and the physiology of reproduction.
People like Joyner want more debate, they do not want scientific progress because they haven’t made any. All the serious scientists who have led the way to the cure for cancer will continue to do so, and people like Joyner will be left behind to contemplate the role of the incidentalome.
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6 MIN READ
0
Methylation maintains cell type differences (2)
2 MIN READ
0
Methylation maintains cell type differences
3 MIN READ
0
Creating nothing but a theory
4 MIN READ
0
Viruses and ecologically adapted animals
2 MIN READ
0
The quantum / classical RNA-mediated ‘tipping point’
3 MIN READ
0
Epigenetic effects of soil bacteria on plants
< 1 MIN READ
0
Epigenetic switch links MicroRNAs to RNA-protein interactions
4 MIN READ
0
Quantum correlations/pseudoscience
3 MIN READ
0
Correctly modeling ecological adaptation
4 MIN READ
0
Questions about life’s diversity
21 MIN READ
0
UV-light mutations and gene loss (not gain)
5 MIN READ
0
RNA-directed gene choice
5 MIN READ
0
Assembling yourself: Molecular self / other recognition
4 MIN READ
0
What about birds?
5 MIN READ
0
RNA directed DNA methylation and cell types
4 MIN READ
0
Implicating microRNAs in cancer
2 MIN READ
0
Reverse phosphorylation
7 MIN READ
0
RNA-mediated repurposing in microbes and adaptations in primate brains
2 MIN READ
0
Atheism: Arrogant, useless, and divisive ignorance
7 MIN READ
0
The anti-entropic force of "Nature"
2 MIN READ
0
Nutritional epigenetics, exercise, and immune system integrity
4 MIN READ
0
Atoms to ecosystems is not almost a molecular ecology
3 MIN READ
0
RNA-mediated epigenetic modification via DNA-methylation
4 MIN READ
0
Sneaking up from behind
4 MIN READ
0
An epigenetic trap (the sequel)
10 MIN READ
0
Environment epigenetically shapes the immune system
3 MIN READ
0
Beneficial microbes kill beneficial mutations
4 MIN READ
0
A single amino acid substitution differentiates cell types of E. coli
3 MIN READ
0
Mutagenesis: Replacing facts with theories
5 MIN READ
0
Amino acid homeostasis for a Happy New Year!
6 MIN READ
0
From Hydra to humans vs a Lakatosian research program
4 MIN READ
0
Unified nutritional and molecular mechanisms
9 MIN READ
0
Communication, not mutations
2 MIN READ
0
Models by evolutionary biologists are not models
2 MIN READ
0
Chemical ecology and RNA-mediated control of DNA loops
< 1 MIN READ
0
Single-cell level assay of protein biosynthesis and degradation
2 MIN READ
0
Glycine and GnRH: Am I being pedantic?
4 MIN READ
0
Extensive molecular evidence vs ridiculous theories
2 MIN READ
0
Meaningful dialogue, anonymous fools and idiot minions
4 MIN READ
0
Sackler Colloquium: Effects or AFFECTS on Behavior
2 MIN READ
0
Thermodynamic constraints and ecological adaptations sans evolution
6 MIN READ
0
Eliminating correlations from evolutionary ecology
6 MIN READ
0
Biologists puzzled by evolved RNAs and decaying DNA
6 MIN READ
0
Achiral GnRH: no prophesy, just prediction
9 MIN READ
0
Nothing new under the sun, except pseudoscientific nonsense
6 MIN READ
0
De novo DNA methylation?
3 MIN READ
0
Pharmacogenomics
3 MIN READ
0
In theory, or supported by experimental evidence?
5 MIN READ
0
It’s cell type differention, not cell fate determination (2)
3 MIN READ
0
Are evolutionary theorists 'nob ends'?
5 MIN READ
2
No excuses: Creation and the meaning of organismal complexity
7 MIN READ
0
Nutrient-dependent gene duplication in plants (but not animals?)
4 MIN READ
0
Evolutionary theorists and evolutionary theists live under rocks
< 1 MIN READ
0
No understanding of biodiversity
2 MIN READ
0
Eliminating evolutionary theory
3 MIN READ
0
Behavioral ecology: please continue to believe in our fantasies
3 MIN READ
0
2014 and 2004 Nobel Prize in Medicine
3 MIN READ
0
How much good can be attributed to social science theories?
< 1 MIN READ
0
RNA-mediated genetic engineering (Part 3)
< 1 MIN READ
0
RNA-mediated events are not a matter of faith
2 MIN READ
0
Color vision refutes the evolutionary dogma of gene duplication
4 MIN READ
0
Different physical locations and different molecular mechanisms of health and disease
2 MIN READ
0
Metabolism, fixation, health or neurodegerative disorder
2 MIN READ
0
Physics denied; pseudoscientific nonsense accepted
2 MIN READ
0
Evolving DNA before RNA
4 MIN READ
0
Stop evolutionary theorists. Kill cancers
3 MIN READ
0
Seemingly futile cycles are not thermodynamically futile
3 MIN READ
0
Social experiences epigenetically effect gene networks
2 MIN READ
0
Pheromone-controlled thermodynamics and cancer
2 MIN READ
0
Functional coding variants are not mutations
2 MIN READ
0
Understanding the role of mutations and evolution
4 MIN READ
0
Evolution: innovations may have non-adaptive origins (sans mutations)
2 MIN READ
0
Hormones effect sensitivity to androsterone
2 MIN READ
0
Music to our ears and song in birds: a common sense approach
2 MIN READ
0
The genetics myth meets the great pheromone myth
2 MIN READ
0
The challenges of a Darwinian approach to anything
3 MIN READ
0
How Species Diversify
2 MIN READ
0
The same neural mechanisms are at work in worms and humans
2 MIN READ
0
Epigenetic effects on the evolution of behavior
2 MIN READ
0
Human pheromones and inner conflict about evolution (1102 words)
4 MIN READ
0
Human pheromones and the visual appeal of other people (Part Three)
2 MIN READ
0
Human pheromones and the visual appeal of other people (Part Two)
2 MIN READ
0
A fallacious leap? Ancestral and derived traits
3 MIN READ
0
Modeling odor processing in microbes, mice, and mankind
2 MIN READ
0
Human Pheromones in Socioaffective Neuroscience & Psychology
2 MIN READ
0
The biology of behavior: Seeing more clearly
< 1 MIN READ
0
Do Pheromones Play a Role in Our Sex Lives: Scientific American
< 1 MIN READ
0
Docosahexaenoic acid and autism: praying for hope, or preying on hope
< 1 MIN READ
0
Timing is key in the proper wiring of the brain: study
2 MIN READ
0
Progress in brain research (e.g., starting over)
< 1 MIN READ
0
Avian recognition of human faces
< 1 MIN READ
0
A lesser role for olfaction and pheromones in humans?
1 MIN READ
0
Pheromones and sexual behavior in birds
< 1 MIN READ
0
