The tipping point (revisited): 81,000 publications (2)
…codes for elements that regulate gene expression, such as transcription factors and microRNAs, which can also have a powerful influence on a person’s disease risk.
Disease risk starts with the virus-driven degradation of messenger RNA, which links changes in the energy-dependent microRNA/messenger RNA balance from mutations to all pathology. Energy-dependent microRNA biogenesis typically prevents the pathology.
See: Virus-mediated export of chromosomal DNA in plants and Variation in proviral content among human genomes mediated by LTR recombination
See: Nutrient-dependent/pheromone-controlled adaptive evolution: a model (2013) and Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (2018)
See: Alphagenomix download a sample report
See for comparison: Human brain samples yield a genomic trove (2018)
…Kevin Mitchell of Trinity College Dublin echoes some of Graur’s concerns. “I’m not fully convinced that we know more today than we did yesterday,” he says. He doubts that a profile of gene expression can define disorders as heterogeneous as schizophrenia or autism—or give new insights into how to treat them.
See also: Mapping the Brain’s Genetic Landscape (2018)
…for all the coordination and dazzling science on display, there is a long way to go before any practical payoff arrives, some experts said.
The prevention of school shootings and other gun violence is the obvious payoff linked to Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults
Kevin J. Mitchell’s book “Innate How the Wiring of Our Brains Shapes Who We Are ” links neo-Darwinian pseudoscientific nonsense to all pathology.
See my review: Ignoring light-activated microRNA biogenesis
He frames his claims in the context of random mutations and evolved biodiversity despite the facts that serious scientists have detailed. For example, ages 10+ can learn how the creation of subatomic particles must be linked from cytosis to biophysically constrained viral latency and sympatric speciation.
The physiology of reproduction is linked to heredity in species from soil bacteria to humans via EDAR V370A (an amino acid substitution) in mice; in populations found in North and East Asia; and in populations in the New World.
I could go on about the facts about cell type differentiation for hours or refer you to MicroRNA.pro or one of my other domains. Alternatively, you could see the work that was published on [10/16/18] today: “MicroRNAs buffer genetic variation at specific temperatures during embryonic development” for comparison to our 1996 review of molecular epigenetics: “From Fertilization to Adult Sexual Behavior“
Autism’s many genetic players may act through common networks