Creation of an enzyme that kills theories (4)
Conclusion: Don’t pretend that fixation of RNA-mediated amino acid substitutions is not all about energy-dependent changes in base pairs or you will be ridiculed.
Excerpt: Protection from viruses is innate and it is obviously energy-dependent. How many more billions of dollars will be spent before population geneticists acknowledge that fact? Who do you think will pay for the therapy?
Apparently, my question has been answered. Ryan Collins et al., blew the whistle on their colleagues at Harvard and MIT.
No one needs to pay for naturally occurring RNA interference unless the facts are placed into the context of RNA-guided human genome engineering
See the web planner: PgmNr 95: Refining the map of genomic disorder loci and associated driver genes by integrating microarray data from 102,257 genomes and exome sequencing of 37,269 individuals.
[The virus-driven] “… deletion-associated genes also exhibited a significant burden of loss-of-function… whereas [food energy dependent biophysically constrained] duplication-associated genes did not. These results demonstrate that rare CNVs and point mutations converge on a shared set of genes and pathways in NDDs, with intriguing distinctions among RGDs and duplications.
Ryan Collins and others like him have linked the difference between a mutation and an amino acid substitution to all food energy-dependent biodiversity on Earth via the physiology of reproduction, which allows only for the fixation of amino acid substitutions. Mutations are not beneficial and they are not fixed in organized genomes unless organisms experience the transgenerational epigenetic effects of nutrient stress or social stress. Then all hell breaks loose.
…the majority of variants [SNPs], including potentially harmful ones, were picked up during the past 5,000–10,000 years.
Don’t pretend that fixation of RNA-mediated amino acid substitutions is not all about energy-dependent changes in base pairs or you will be ridiculed.