Energy-dependent thymic involution vs evolution (1)
(click to enlarge)Historical perspective:
See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)
The synthesis of RNA in isolated thymus nuclei is ATP dependent.
Mapping natural genetic variants that modulate RNA processing responses (response QTLs)…
Genetic variants do not modulate RNA processing responses.
See: A Quick HYL1-Dependent Reactivation of MicroRNA Production Is Required for a Proper Developmental Response after Extended Periods of Light Deprivation (2018)
…plants alter microRNA (miRNA) biogenesis in response to light transition.
The creation of sunlight has been linked from microRNA biogenesis to the creation of RNA and to alternative splicings of pre-messenger RNA (pre-mRNA) that link the physiology of reproduction to fixation of the amino acid substitutions. Light-activated RNA-directed DNA methylation links the alternative splicings of pre-mRNA to the differentiation of all cell types in all individuals of all living genera.
See also: MicroRNA Functions in Thymic Biology: Thymic Development and Involution (2018)
Re:
…organogenesis (cell migration, proliferation, and differentiation), development (proliferation, differentiation, and cell apoptosis), and involution (cell senescence and apoptosis).
Perspectives
MiRNAs play important roles in the processes of thymus organogenesis, maturation, and involution at a post-transcriptional level by targeting relevant mRNAs. Herein, we reviewed some of the miRNAs involved in thymocyte development, thymic architecture, thymic aging involution, and thymic involution during stress. We hope this review will help to deepen the appreciation of miRNA impact on thymic biology and facilitate the identification of potential candidates for therapeutic targeting. In addition, we checked miRNA profiles of serum-derived exosomes from young and aged mice with microarray of Mus musculus miRBase version-21 array chips and we found that young and old showed different miRNA expression profiles (112). These different spectrums of microRNAs in the young and old exosomes may generate a base for a potential epigenetic regulation and may play important roles in the processes of thymus organogenesis, maturation, and involution.
See also: US Air Force Studying Impact of Exome Sequencing in Routine Care
After exome testing is performed on patients, their doctors will get a report listing the pathogenic and likely pathogenic variants related to dominant and recessive monogenic conditions, risks for complex diseases, and response to drugs. These results will be entered into the service members’ electronic medical records.
Exome Sequencing in Routine Care is the key to “Precision Medicine.” Therefore, Christine M. Blasey Ford’s history of published works can now be viewed as a threat to Homeland Security. Her focus is on the pseudoscientific nonsense touted by theorists who have failed to link the creation of sunlight to protection from the virus-driven degradation of messenger RNA, which serious scientists have linked to all pathology during the past 53 years.
See for comparison:
Psychological Flexibility and Set-Shifting Among Veterans Participating in a Yoga Program: A Pilot Study (2018)
Meditation with yoga, group therapy with hypnosis, and psychoeducation for long-term depressed mood: a randomized pilot trial (2008)
During the past decade, the works of biologically uninformed science idiots like Christine M. Blasey Ford have contributed to the deaths by suicide, which reportedly now occur at a rate of ~22 each day.
The stress that she induced with her accusations against Judge Brett Kavanaugh has altered his life course, perhaps permanently. Those accusations became the focus of a congressional hearing during which she appears to have repeatedly lied. Whether or not she was coached on how to effectively lie by those who also present a threat to Homeland Security, we may never know. But when it comes to the creation of the sun and prevention or effective treatment of all virus-driven pathology up to and including virus-driven suicide, it appears that many Democrats would like to cause outstanding examples of human potential, like Brett Kavanaugh and others, to commit stress-linked suicide.
Thank God, he could be bent without breaking, just like the light-tracking Brugmansia (Angel Trumpet) in the photo that appears in this blog post.
See also: FBI investigation of Christine M. Blasey Ford?
