Natural models inspire future therapeutics (2)
See for comparison: Identification of miR-379/miR-656 (C14MC) cluster downregulation and associated epigenetic and transcription regulatory mechanism in oligodendrogliomas.
The post- transcriptionally regulatory network of this cluster showed enrichment of key cancer-related biological processes such as cell adhesion and migration. Also, there was enrichment of several cancer related pathways viz PIK3 signaling pathway and glioma pathways. Survival analysis demonstrated association of C14MC (miR-487b and miR-409-3p) with poor progression free survival in ODGs.
CONCLUSION: Our work demonstrates tumor-suppressive role of C14MC and its role in pathogenesis of ODGs and therefore could be relevant for the development of new therapeutic strategies.
The epigenetic and transcription regulatory mechanisms of all cell types are quantized energy-dependent and microRNA-mediated. See “MicroRNA.”
Acknowledging the fact that the virus-driven theft of quantized energy has been linked from the degradation of messenger RNA to all pathology in all living genera is relevant to new therapeutic strategies.
For example, food odors and pheromones biophysically constrain viral latency, and an effective treatment for all neurodegenerative diseases was proposed in this 2011 patent application “Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis”
See for comparison: Calcium, conformational selection, and redox-active tyrosine YZ in the photosynthetic oxygen-evolving cluster
This was reported for biologically uninformed science idiots who work in the lab as: “Making the Oxygen We Breathe, a Photosynthesis Mechanism Exposed”
About two billion years ago, the photosynthesis that generates O2 exploded, and as breathable oxygen filled Earth’s oceans and atmosphere, life began evolving into the complex variety we have today.
See: Virus-mediated archaeal hecatomb in the deep seafloor
It is the physiology of quantized energy-dependent pheromone-controlled reproduction in bacteria that constrains the virus-mediated archaeal hecatomb and all pathology on Earth. To see the claim about photosynthesis placed into the context of neo-Darwinin evolution is an insult to the intelligence of all medical laboratory personnel.
Watch these theorists try to put what is known to all serious scientists back into the context of big bang cosmology and neo-Darwinian evolution. Watch as others try to explain why they missed what they missed about quantized energy as the source that links top-down causation to all biophysically constrained phenotypic expression via the physiology of reproduction and sympatric speciation.
See for review
An expanded view of complex traits: from polygenic to omnigenic 6/15/17
Common Disease Is More Complex Than Implied by the Core Gene Omnigenic Model 6/14/18
Reported as: Theory Suggests That All Genes Affect Every Complex Trait 6/20/18
The quantized energy-dependent creation of microRNAs has been linked from the RNA-mediated creation of genes to every complex trait via sympatric speciation.
See for comparison: Nutrient-dependent/pheromone-controlled adaptive evolution: a model 6/14/13