Quantized energy-dependent mTORC1 and autophagy

Conclusion: One side of this representation of the global metabolic shift links food energy-dependent microRNA biosynthesis to healthy longevity. The other side of the global metabolic shift links the virus-driven theft of quantized energy from autophagy to catabolism. Biologically uninformed theorists link catabolism from mutations to evolution. Serious scientists link fixation of RNA-mediated amino acid substitutions to cell type differentiation and all biophysically constrained biodiversity.

Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1

Excerpt 1)

VacA perturbations in mitochondria are linked to alterations in cellular amino acid homeostasis, which results in the inhibition of mammalian target of rapamycin complex 1 (mTORC1) and subsequent autophagy.

Excerpt 2)

…bolstering amino acid pools prevents VacA-mediated mTORC1 inhibition. Overall, these studies support a model that Hp modulate host cell metabolism through the action of VacA at mitochondria.

How might that model be linked from mutations to evolution for comparison to my model of ecological variation and food energy-dependent pheromone-controlled ecological adaptations?

We show here for the first time the crucial role of viruses in controlling archaeal dynamics and therefore the functioning of deep-sea ecosystems, and suggest that virus-archaea interactions play a central role in global biogeochemical cycles.

See also: Introduction to special Carl Woese issue in RNA Biology

“…we discussed and debated what came first, proteins or DNA in Dr Russell Doolittle’s “Biochemical Evolution” class. That fall I learned that Carl (and my PhD adviser, Dr Harry Noller!) had the audacity to proclaim, “NEITHER, RNA came first.”

McEwen et al., (1964) linked the quantized energy-dependent creation of ATP to the creation of RNA. That placed the facts into the context of Schrodinger’s claims in “What is Life?” (1944). All serious scientists have since followed Schrodinger’s lead and McEwen’s lead. Most of them realize that life is quantized energy-dependent and that the quantized energy is biophysically constrained in the food that organisms eat. That allows them to link the metabolism of food to the pheromones that biophysically constrain viral latency, and to dispense with the pseudoscientific nonsense of neo-Darwinian evolution.
See also: Schrödinger at 75 – The Future of Biology – September 2018
See also: Opinion: Archaea Is Our Evolutionary Sister, Not Mother

if archaea are indeed our sisters and not our mothers, one could imagine that some common features present in Bacteria and Eukarya have been inherited from the last universal common ancestor (LUCA) of all life and subsequently lost in Archaea.

Archaea exemplify what happens in the context of the virus-driven theft of quantized energy from bacteria with degraded messenger RNA. They are the last stop before L-forms. They are not our sisters and there is only one domain of quantized energy-dependent life. Life biophysically constrains viral latency. Archaea and L-forms are losers.