The eternal significance of microRNAs (2)

By: James V. Kohl | Published on: April 12, 2018

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Summary: What is known for sure, however, is that biological processes called “nature” are not simplistic. Neither is the entity called “the environment.” The two separate worlds overlap and intertwine so only a single interactive one exists. Yes, it may be simpler to look at each singly, but one does so at intellectual peril.
The Immune Landscape of Cancer (2018)

Multiple control modalities of the intracellular and extracellular networks (transcription, microRNAs, copy number, and epigenetic processes) were involved in tumor-immune cell interactions, both across and within immune subtypes.

More than 725 collaborators linked the anti-entropic virucidal energy of sunlight from the energy-dependent creation of microRNAs and biophysically constrained viral latency to cell type differentiation via autophagy.
See for comparison: From Fertilization to Adult Sexual Behavior (1996)

What is known for sure, however, is that biological processes called “nature” are not simplistic. Neither is the entity called “the environment.” The two separate worlds overlap and intertwine so only a single interactive one exists. Yes, it may be simpler to look at each singly, but one does so at intellectual peril.

Richard P. Feynman placed the intellectual peril into the context of food energy and human idiocy.
See:

See also: The Translation Machinery Is Immune from miRNA Perturbations: A Cell-Based Probabilistic Approach

Mature microRNAs (miRNAs) are non-coding RNA that regulate most human genes through base-pairing with their targets.

Base-pairing is energy-dependent and biophysically constrained. See: Structural diversity of supercoiled DNA and the parody: All About that Base (Meghan Trainor Parody) 12/10/14
Others now appear to be following on the heels of the late Eshel Ben-Jacob’s works, which showed that the “stochastic nature of miRNA action” is light energy-dependent and biophysically constrained by the physiology of pheromone-controlled reproduction in species from microbes to humans.
See: MicroRNA-based regulation of epithelial–hybrid–mesenchymal fate determination
MicroRNA-based regulation is obviously the key to biophysically constrained viral latency in the context of everything known about the eternal significance of microRNAs.
See also: microRNA
The quantized energy-dependent differential expression of microRNAs has been linked to healthy longevity or from virus-driven energy theft to all pathology in more than 71,000 indexed published works.
Serious scientists now know that John McCain’s glioblastoma can probably be effectively treated with the microRNA-mediated immunotherapy that led to the remission of Jimmy Carter’s brain cancer.
See: John McCain’s brain cancer prognosis is ‘not very good,’ medical expert says
The reporters touch on the likely link from melanoma to brain cancer via microRNAs, and then dismiss it.
See for comparison: Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene
Would you like to target the regulation of your cell death genes?
See: The Remarkable Cancer Treatment That Helped Jimmy Carter Combat Brain Tumor

…his doctors have said he no longer needs cancer treatment thanks in part to a groundbreaking new kind of medication that trains the immune system to fight cancer tumors.

Anyone who is interested in learning how to prevent all diseases of the body and the brain (e.g., suicide prevention) may want to select the following link. Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis.
The Warburg Effect links virus-driven energy theft to all pathology in the context of sympatric speciation, which is food energy-dependent and controlled by feedback loops that link the food energy to the pheromone-controlled physiology of reproduction.
Unfortunately, the Warburg effect is commonly used to explain mutation-driven evolution outside the context of the food energy that is required for sympatric speciation. Biologically uninformed theorists continue to display what Feynman referred to as human idiocy — as if no one on Earth can stop them.
But see: Cytosis. You could learn that the cure for all pathology is food energy-dependent and microRNA-mediated in the context of biophysically constrained viral latency.
See also: Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution
Anyone who makes claims about “viral evolution” should be forced to explain why they have not learned how fixation of RNA-mediated amino acid substitutions have been linked to healthy longevity.

Editor’s summary: Five antigenic sites in the virus surface hemagglutinin protein, which together comprise 131 amino acid positions, are thought to determine the full scope of antigenic drift of influenza A virus. Koel et al. (p. 976) show that major antigenic change can be caused by single amino acid substitutions.

Brain gene expression profiling studies of suicide and depression using oligonucleotide microarrays have often failed to distinguish these two phenotypes. Moreover, next generation sequencing approaches are more accurate in quantifying gene expression and can detect alternative splicing.

Who doesn’t want others to know that our 1996 Hormones and Behavior review of RNA-mediated cell type differentiation included a section on “molecular epigenetics” and alternative splicing? See: From Fertilization to Adult Sexual Behavior

The eternal significance of microRNAs (2)

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