MicroRNAs biophysically constrain behavior (2)
Researchers, like Shunsuke Suzuki, who cannot link photonic coupling from quantum physics to biophysically constrained atomic energy via classical physics and quantum chemistry prevent scientific progress, They are limited to asking questions that have already been answered by serious scientists.
MicroRNA 1-20 of more than 70,400
The fact that the energy-dependent creation of microRNAs links RNA-mediated cell type-differentiation to biophysically constrained viral latency and all morphological phenotypes has been established.
See: PAN-cancer analysis of S-phase enriched lncRNAs identifies oncogenic drivers and biomarkers
…using nascent RNA capture sequencing, we identify 1145 temporally expressed S-phase-enriched lncRNAs. Among these, 570 lncRNAs show significant differential expression in at least one tumor type across TCGA data sets.
Reported as: RNA-based therapy cures lung cancer in mouse models
By turning down the activity of a specific RNA molecule researchers at Sahlgrenska Academy, Sweden, have cured lung tumors in mice by 40-50 percent. The results, published in Nature Communications, represent the tip of the iceberg in an extensive research project in which 633 new biomarkers for 14 types of cancer have been identified.
Ongoing support for my model of Energy as information and constrained endogenous RNA interference continues to link RNA-mediated differences in human populations to biophysically constrained viral latency and survival. Why haven’t others accepted the fact that there must be a link from the RNA-mediated differences to behavior? Morphological and behavioral phenotypes are energy-dependent and receptor-mediated.
See: Vital Signs: Racial Disparities in Age-Specific Mortality Among Blacks or African Americans — United States, 1999–2015
1) Vascular Endothelial Growth Factor Receptor 3 Controls Neural Stem Cell Activation in Mice and Humans (2015)
2) Delayed Dopamine Signaling of Energy Level Builds Appetitive Long-Term Memory in Drosophila (2015)
Reported as: Fruit flies remember a good meal, Blood growth factor activates neural stem cells
…the fruit fly brain is wired to remember and crave sweeter, energy-rich foods. After smelling and consuming a meal, such as a glob of sugar, information about the food’s energy content is relayed via dopaminergic neurons to a fruit fly’s olfactory long-term memory center.
The ability to remember a good meal is linked to a single amino acid substitution in one or more receptors.
3) A Single Amino Acid Substitution in the Activation Loop Defines the Decoy Characteristic of VEGFR-1/FLT-1 (2006)
The link from the food energy-dependent creation of microRNAs and the creation of enzymes to the single amino acid substitution that controls receptor-mediated neural step cell activation in mice and humans may not be obvious. For instance, the acronym VEGFR might not be linked to other reports on Vascular Endothelial Growth Factor Receptors.
The likelihood of establishing facts about top-down causation and biophysically constrained viral latency is reduced as each step towards neo-Darwinian pseudoscientific nonsense brings another level of obfuscation. See for example:
Duplicated genes are abundant in eukaryotic genomes and thus are presumed to play important roles in evolution.
Duplicated genes do not create themselves. The de novo creation of genes is energy-dependent and receptor-mediated. That fact establishes all the links from top-down causation to biophysically constrained viral latency and ecological adaptations via the creation of RNA and energy-dependent fixation of RNA-mediated amino acid substitutions.
If serious scientists understand the facts about food energy-dependent pheromone-controlled ecological adaptations in species from microbes to humans, questions like this are not likely to arise. VEGF165b elevation in pulmonary arterial hypertension patients, causative or adaptive? (4/1/18)
No reply is required. But see: VEGF165b elevation in pulmonary arterial hypertension patients, causative or adaptive? -Reply. (4/1/18)
Shunsuke Suzuki is a co-author of the reply. I am not interested in reading about questions or replies that are placed into the context of ridiculous theories, or attending meetings on Epigenetics & Chromatin where discussion of the emergence of novel CpG islands and genomic imprinting in mammalian evolution are discussed.
See for comparison: Direct Photonic Coupling of a Semiconductor Quantum Dot and a Trapped Ion (2015)
Understanding the key role played by single atoms and ions in the context of elementary quantum information processing protocols is required to answer questions about top-down causation and adaptation. Researchers, like Shunsuke Suzuki, who cannot link photonic coupling from quantum physics to biophysically constrained atomic energy via classical physics and quantum chemistry prevent scientific progress, They are limited to asking questions that have already been answered by serious scientists.
See Frohlich (1968) Long-range coherence and energy storage in biological systems
The supplied energy is thus not completely thermalized but stored in a highly ordered fashion.
See also: Schrödinger at 75 – The Future of Biology – September 5-6, 2018
The future of biology lies in the understanding of how the creation of the sun’s anti-entropic energy links RNA-mediated top-down causation via natural selection for energy-dependent codon optimality in the context of novel CpG islands and genomic imprinting. The RNA-mediated genomic imprinting must be linked to biophysically constrained viral latency. It is ridiculous to link the systems complexity of cell type differentiation and cancer prevention to mammalian evolution without consideration of how behavior could be linked to biophysically constrained cell type differentiation.
See for instance: CpG islands microRNA