The MicroRNAome Strikes Back: A Sokalian hoax (8)
Defeating Diseases with Energy (January 9, 2018) is a thinly disguised attempt to help corporate giants continue to promote ridiculous neo-Darwinian theories. It features the works of Douglas C. Wallace, who failed to link the virus-driven degradation of messenger RNA to all pathology since he published: Neoplastic transformation is associated with coordinate induction of nuclear and cytoplasmic oxidative phosphorylation genes (1990).
Similar analysis of a cervical carcinoma (HeLa), fibrosarcoma (HT1080), and an Epstein-Barr virus (EBV)-transformed lymphoblastoid line (EBV-L) revealed that all three ANT isoforms were also expressed in these cells. Hence, changes in the expression of OXPHOS genes may be a common feature of transformed cells.
Did he not recognize the significance of the energy-dependent transformation of adenine (in the context of the adenine nucleotide translocator) and oxidative phosphorylation (OXPHOS) genes?
Did Douglas C. Wallace introduce the world to the pervasive nature of the first biologically-based Sokalian hoax, which was subsequently used to bastardize everything known to serious scientists about molecular epigenetics?
Is that how you become a corporate “Champion of Science?”
See for comparison: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)
Why isn’t Bruce McEwen a corporate “Champion of Science” in the context of his claims about the food energy-dependent creation of RNA via a type of “oxidative phosphorylation?”
When will so-called science journalists realize the difference between a serious scientist like Bruce McEwen and a pseudoscientist like Douglas C. Wallace?
Simply put, the difference is in their approach to explaining how biophysically constrained energy-dependent changes in base pairs are linked from fixation of RNA-mediated amino acid substitutions to the differentiation of all cell types. In all living genera, fixation of RNA-mediated amino acid substitutions occurs in the context of the physiology of pheromone-controlled reproduction, which links feedback loops to all biodiversity.
People like Douglas C. Wallace claim that “evolution did it.” Serious scientists put his ridiculous claim into the context of experimental evidence of biophysically constrained energy storage.
See: Long-range coherence and energy storage in biological systems (1968)
Energy storage begins with the creation of energy and ends with the virus-driven degradation of messenger RNA that links mutations to all pathology. How many more victims of Sokalian hoaxes will there be? Who will help to prevent the next viral apocalypse? Will it be the “Trump Administration?”
I think that fact is obvious.
See: Double-layered protein nanoparticles induce broad protection against divergent influenza A viruses
The amino acid sequence of influenza matrix protein 2 ectodomain (M2e) is highly conserved among human seasonal influenza A viruses20.
“Vaccination is the most effective way to prevent deaths from influenza virus, but the virus changes very fast and you have to receive a new vaccination each year,”
Exosomes regulate cell-cell communication by transferring functional proteins and RNAs between cells. Here, to clarify the function of exosomes during influenza virus infection, we characterized lung-derived exosomal microRNAs (miRNAs).
For comparison see this Sokalian hoax: Comparison of miRNA evolution and function in plants and animals
MicroRNAs (miRNAs), as a major player in post-transcriptional regulation of gene expression, have been reported to regulate a broad variety of key biological processes, including growth, development and stress responses in both plants and animals. While the biogenesis and regulatory abilities of miRNAs have been extensively studied, the evolutionary history of miRNAs still needs more exploration. So far, several models explain the origination of plant and animal MIRNA (MIR) genes. Both inter-species and intra-species conservation and divergence of miRNAs exhibits functional adaptation to changing environments in evolution. Here we summarize recent progress in how these similarities and differences contribute to the characteristic features of miRNA evolution in the two kingdoms.
MicroRNAs do not have an evolutionary history. They link the creation of the sun to the creation of ATP to the creation of RNA. ATP did not evolve. RNA did not evolve. Amino acids did not evolve. Viruses do not evolve.
Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution
See the NIH report: Flu infection study increases understanding of natural immunity
Natural immunity did not evolve!
For a historical perspective on the ridiculous claims about evolution, see: Neo-Darwinism has failed as an evolutionary theory (May, 1995) by Brian Goodwin
To understand why organisms look the way they do we need models that involve physical forces as well as biological variables, organised to produce organisms with specific morphologies, as described in my book, How the Leopard Changed its Spots.
See: Brian Goodwin:
In a critical review, biologist Catherine S. C. Price noted that although he had succeeded in providing an alternative to mutation as the only source of variation, he failed to provide an alternative to natural selection as a mechanism of adaptation.
That claim has been echoed in the literature published by pseudoscients and so-called science journalists for more than two decades. Natural selection for food energy-dependent codon optimality has repeatedly been linked from the pheromone-controlled physiology of reproduction to all biophysically constrained biodiversity and ecological adaptation since the time we published The Scent of Eros: Mysteries of Odor in Human Sexuality (first published in May, 1995)
Helen Fisher said this about The scent of eros: mysteries of odor in human sexuality (by Kohl and Francoeur 1995): “This is science at its best, with adventure, ideas, and lots of facts.”
Reviewed by Mark Sergeant
Reviewed by Ralph Underwager, Institute for Psychological Therapies
Reviewed by Jan Peregrine
See also: 6 Amazon.com customer reviews
No experimental evidence of biologically-based cause and effect supports the ridiculous claims that Catherine S. C. Price, and others like her, seem to think link mutations to the molecular mechanisms of adaptation via natural selection. That fact explains why theorists must invent new theories and claim to be reconceptualizing their past pseudoscientific nonsense.
See: Theme issue ‘Re-conceptualizing the origins of life’ compiled and edited by Sara Walker and George Cody
For example: Review article: Exploring astrobiology using in silico molecular structure generation
See for comparison: Jerry Fodor Held High Ground to Evolution’s Militant Fundamentalists
Astrobiology doesn’t exist. What are its laws?
See also: The First Virus Communication Signals