The MicroRNAome Strikes Back: A Sokalian hoax (1)
Summary: How can this not be a Sokalian hoax? The creation of sunlight is not linked to anti-entropic virucidal energy-dependent cell-type-specific epigenetic modifications. The quantized energy-dependent epigenetic modifications include RNA-directed DNA methylation, histone modification, nucleosome remodeling and higher-order chromatin reorganization. Instead, the magic of non-cell autonomous DNA methylation in plants is placed into in the context of the cytosine residue in CG, CHG and CHH sequence contexts (where H represents A, T or C).
See for comparison: Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants January 2013
Reported as: Past 5,000 years prolific for changes to human genome
The findings confirm their earlier work suggesting that the majority of variants, including potentially harmful ones, were picked up during the past 5,000–10,000 years.
The variants are food energy-dependent and biophysically constrained by the physiology of pheromone-controlled reproduction in the context of the transgenerational epigenetic inheritance of all morphological and behavioral phenotypes.
See also: The palaeolithic diet and the unprovable links to our past November 2014
The picture is rapidly emerging that genetics play a pretty minor role in determining the specifics of our diet. Our physical and cultural environment mostly determines what we eat.
That fact can be placed into the context of how the physical environment of plant growth determines what cattle eat and how the food energy-dependent microRNAome prevents the virus-driven degradation of messenger RNA in the context of the transgenerational epigenetic inheritance of healthy longevity.
See for instance: The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression December 2014
In the last few decades, sperm have been reported to carry both RNA and microRNA to the fertilized zygote , . MicroRNA (miRNA) are important regulators in translation, and their altered expression often leads to disease or cancer.
The anti-entropic virucidal efffect of sunlight (see: Schrodinger, 1944) on soil bacteria and plant growth is linked from the physiology of pheromone-controlled reproduction in soil bacteria to all biophysically constrained energy-dependent cell type differentiation in all living genera via changes in base pairs, microRNA editing, RNA editing and the hydrogen-atom transfer in DNA base pairs in solution, which is required for energy-dependent RNA-mediated DNA repair.
That fact led to another Sokalian-like hoax. See for review The Sokal Hoax [quantum gravity]:The Sham That Shook the Academy
gravity, Sokal argued, was a fiction that society had agreed upon, and science needed to be liberated from its ideological blinders.
The original Sokal hoax about the obvious facts linked to gravity appears to have set the precedent for Nonomura’s monograph. In the context of word usage by Richard P. Feynman, this example of human idiocy can be used to show that nothing has changed in the world of biologically uninformed theorists. They still have not linked quantum physics to biophysically constrained life on Earth.
Nonomura indirectly argues that the quantized energy of virucidal light is not required to link sunlight from cell type differentiation in plants to all biophysically constrained biodiversity in animals. He, like many others, provides details about the conserved molecular mechanisms of RNA-mediated cell type differentiation. But Nonomura, like Masatoshi Nei, in Mutation-driven evolution, starts with the pathways and asks that others ignore the facts about sunlight.
Sokal asked that others ignore the facts about gravity. Nonomura’s follow-up is brilliant!
Ignore sunlight! Ignore the link from sunlight to plant growth! Ignore food energy! Display your level of human idiocy.
See how the hoaxes ridicule peer-review: List of scholarly publishing hoaxes
The list of nonsense papers does not include cases of scientific misconduct. The intent
Especially in grass species, 21- and 24-nucleotide phasiRNAs are abundant in anthers during premeiosis and meiosis.
In the context of “non-autonomous regulation” microRNAs become small RNAs, which become small interfering RNAs (siRNAs) that become: trans-acting siRNA (tasiRNA) and phased secondary siRNA (phasiRNA) in the context of claims about the evolution of eukaryotic species to land plants. The land plants have somehow evolved a unique non-cell autonomous epigenetically-effected mode of reproduction that is not linked to the energy-dependent creation of the microRNAs.
The epigenetically-effected pathways of energy-dependent non-cell-autonomous regulation are placed into the context of automagical cell type differentiation via microRNA-mediated biophyiscally constrained viral latency until the time comes to claim that genetic and epigenetic regulation must differ between the germline and somatic companions. After that, the author tries to explain how the small RNAs (e.g., microRNAs, siRNAs, tasiRNA, phasiRNA) are linked from nutrient energy-dependent pheromone-controlled viral latency in my model. Every aspect of food energy-dependent RNA-mediated cell type differentiation in animals begins with the non-cell-autonomous regulation of somatic-to-reproductive cell communication in model plants.
What then, is non-cell autonomous regulation? Is it magic?
…sperm and egg cells develop as part of the multicellular gametophyte. Thus, the non-cell-autonomous regulation by somatic companions plays important roles in efficient reproduction, in addition to the cell-autonomous regulation. Epigenetic silencing of transposable elements is one of the central events by which the germline transmits the error-free genome to the next generation.
The transfer of the error-free genome to the next generation is food energy-dependent and the pheromone-controlled physiology of reproduction typically ensures transmission of the error-free genome to the next generation.
How can Nonomura’s most recent publication not be a Sokalian hoax? The creation of sunlight is not linked to anti-entropic virucidal energy-dependent cell-type-specific epigenetic modifications. The quantized energy-dependent epigenetic modifications include RNA-directed DNA methylation, histone modification, nucleosome remodeling and higher-order chromatin reorganization. Instead, the magic of non-cell autonomous DNA methylation in plants is placed into in the context of the cytosine residue in CG, CHG and CHH sequence contexts (where H represents A, T or C).
That magic extends to the magic of non-cell-autonomous cell type differentiation, which somehow defines all biophysically constrained cellular identities during the development of unicellular organisms or multicellular organisms.
But see for comparison from 1999 (First author is KI Nonomura): Organization of the 1.9-kb repeat unit RCE1 in the centromeric region of rice chromosomes.
The organization of chromosomes links everything known to serious scientists about the energy-dependent creation of supercoiled DNA to all biophysically constrained viral latency via the physiology of reproduction and energy-dependent microRNA-mediated mechanisms of recombination.
See: Mechanisms of Recombination conference
See also: What should I do with my life?
This is somewhat silly advice from the company that discovered how to epigeneticallly prevents activation of the death gene. Use the information from them to help drain the academic and to help drain the political swamp. Help yourself live a healthy life by helping the Trump administration make America great again. Limit the ability of others to make money from your unnecessary suffering and premature death,