Kinetically Stable Thermodynamically Activated Cell Metabolism (3)

By: James V. Kohl | Published on: December 25, 2017

See: The vibrational theory of olfaction for the win

The same kinds of amino acid substitutions that control the separations and interactions of side chains in fluorescent proteins also play an essential role in tuning the proposed mechanism for vibration detection—inelastic electron tunneling. Life literally runs on electron tunneling through the respiratory chain complexes in mitochondria.

See also: The Influence of Circadian Timing on Olfactory Sensitivity
Reported as: The Circadian Clock in Your Nose

“The results make sense — the circadian clock affects virtually every organ system in the body,” writes Dr. Leslie Vosshall, a researcher at Rockefeller University who studies smell and was not involved in the study, in an email.

Vosshall failed to link the energy-dependent de novo creation of olfactory receptor genes from Luca Turin’s facts about vibrations and olfaction to the fixation of RNA-mediated amino acid substitutions in the cell types of mosquitoes that determine their ability to detect human body odors.
Simply put, life literally runs on energy and the quantized energy of life is biophysically constrained by the pheromone-controlled fixation of amino acid substitutions in the organized genomes of species from microbes to humans. The life of Vosshall’s funding for  pseudoscientific nonsense may have ended.
See: Targeted mutagenesis of Ae. aegypti orco

a, Snake plot of Ae. aegypti Orco with amino acids colour-coded to indicate conservation with Drosophila melanogaster. The amino acids encoded by the DNA bound by the orco ZFN (blue) and the epitope of the Drosophila anti-Orco antibody (green) are indicated.

Mutagenesis experiments are of little value when researchers do not know that the virus-driven degradation of messenger RNA causes all mutations. Leslie Vosshall and others like her don’t “get it.”
See for comparison: Structural diversity of supercoiled DNA
In 2014, I wrote to Vosshall to tell her about this forthcoming SFN presentation: Gene co-expression network analysis in a free-living, behaviorally polymorphic species gene co-expression network.  Prior works from Donna Maney’s lab linked different feeding patterns in white-throated sparrows from an amino acid substitution to chromosomal rearrangements in the behavioral morphs. Unlike other groups, Donna Maney’s group has not portrayed the differences in amino acid substitutions as if they were mutations.
I had previewed the Nov 18, 2014 presentation by Wendy Zinzow-Kramer, and discussed with her the fact that it appeared to link genetic networks and metabolic networks via at least one enzyme. That’s why I thought Vosshall might be interested. In retrospect, it seems that Vosshall knows nothing about how to link odor-induced receptor-mediated chromatin remodeling to chromosomal rearrangements via the de novo creation of enzymes or via a nutrient-dependent amino acid substitution. For instance, fixation of enzyme-dependent RNA-mediated amino acid substitutions is linked from the physiology of pheromone-controlled reproduction to all biodiversity in species from microbes to man.
I had hoped that Leslie Vosshall would encourage Wendy Zinzow-Kramer to focus on the across-species link from invertebrates to vertebrates in the experiments that Wendy would be performing as a wonderfully personable post-doc. Later, I learned that Leslie Vosshall thought my published works were examples of pseudoscience.
See this for comparison to Leslie Vosshall’s pseudoscientific nonsense:The secret to safe DNA repair 2015

One of the steps towards preventing cancer is regulating safe DNA repair, and Dr. Michael Hendzel from the University of Alberta just got a little bit closer by discovering RNF138, a protein that helps facilitate the DNA repair process.

“If you don’t have this enzyme, then error-free repair is stopped. If you can’t do the error-free repair, you expect these cells to be cancer prone.”

The claim that one enzyme makes the difference between error-free repair and cancer prone cell types makes sense in the context of what is known to all serious scientists about energy-dependent autophagy.
See: Researchers exploit rhythm of DNA replication to kill cancer cells

New DNA is generated in human cells from tiny building blocks called nucleotides produced by an enzyme called RNR [ribonucleotide reductase (RNR)]. Until now, we have not fully understood how exactly the RNR rhythm and the presence of right amount of nucleotides are aligned with the pace of DNA replication.

Human pheromones, and the pheromone-controlled physiology of reproduction in species from microbes to humans, biophysically constrain the amino acid substitutions that biophysically constrain viral latency in the context of autophagy.
The rhythm requires pulses (and pauses). See: The science of baby’s first sight.

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