Dispelling the ignorance of theorists
Summary: The highest-order of energy-dependent pre-assembly of respiratory chain complexes allows mitochondria to respond to energy-requiring conditions. There is no such thing as the emergence of energy, self-assembly, self-organization or any other pseudoscientific nonsense touted by theorists. Their theories exemplify what Richard P. Feynman referred to as “human idiocy.” That is why I refer to theorists who argue with me as “biologically uninformed science idiots.” Friends sometimes tell me I am being too harsh, and some of my friends think I am calling them “idiots.” What do you think theorists should be called in attempts to accurately detail the amount of unnecessary suffering and the number of premature deaths they have caused?
See first: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)
The synthesis of RNA in isolated thymus nuclei is ATP dependent. … the required ATP is produced by reactions associated with glycolysis, the citric acid cycle, and a type of oxidative phosphorylation. These pathways can be selectively inhibited by iodoacetate, fluoroacetate, and antymycin A, and RNA synthesis is blocked in the presence of these inhibitors. However, CO, which inhibits mitochondrial oxidative phosphorylation but does not block nuclear ATP synthesis, does not affect RNA synthesis in isolated nuclei or in whole cells. The use of CO as a selective inhibitor of mitochondrial ATP synthesis has made it possible to suppress cytoplasmic protein synthesis while allowing nuclear protein synthesis to continue.
McEwen et al., (1964) has been virtually ignored as the peer-reviewed published link from the creation of energy as information to all biodiversity via the creation of ATP and RNA. Finally, other serious scientists are dispelling the ignorance.
See: Runyu Guo et al. Architecture of Human Mitochondrial Respiratory Megacomplex I 2 III 2 IV 2, Cell (2017). DOI: 10.1016/j.cell.2017.07.050
The respiratory megacomplex represents the highest-order assembly of respiratory chain complexes, and it allows mitochondria to respond to energy-requiring conditions.
This review integrates data from the evolutionarily conserved structure and function of intercellular projections in bacteria with recent developments in mitochondrial imaging that permit nanotunnel visualization in eukaryotes. Cell type-specificity, timescales, and the selective size-based diffusion of biomolecules along nanotunnels are also discussed.
Cell type specificity is energy-dependent and RNA-mediated in the context of the physiology of pheromone-controlled reproduction which links foraging behavior from what organisms eat to their biophysically constrained life as a species among all the other extant species on Earth. RNA-mediated amino acid substitutions in organized genomes link the energy of life from information to the transgenerational epigenetic inheritance of healthy longevity. The virus-driven theft of quantized energy links the degradation of messenger RNA from mutations to all pathology.
That fact was indirectly included in this report by John Hewitt:
Complete structure of mitochondrial respiratory supercomplex decoded reported by John Hewitt
They were also able to identify preferred or most efficient electron transfer pathways, which in turn constrain how many electrons can simultaneously be transferred among active carriers.
SARCASM ALERT: Do you think this may be important to our understanding of how energy-dependent changes are linked from subatomic particles (e.g., electrons et al.) to biophysically constrained ecosystems by the epigenetic effects of food odors and pheromones on RNA-mediated cell type differentiation, which protects all organized genomes from the virus-driven degradation of messenger RNA, which has been linked from mutations to all pathology?
Here’s why I asked: See: Investigating biomolecular recognition at the cell surface using atomic force microscopy. The authors cited an award-winning review at the end of this claim.
The fission yeast pheromone receptor is a kind of G protein-coupled receptor (GPCR), a typical membrane receptor protein oncell surface. These receptors are activated by pheromone binding and then enable cellular signal transduction (Kohl et al., 2001).
Kohl et al., (2001) is the award-winning review: Human pheromones: integrating neuroendocrinology and ethology
Everything else I have published or presented has been linked from endogenous (pre-existing) substrates in all cell types to energy-dependent biomolecular recognition via the innate (pre-existing) immune system, endogenous RNA interference and the advice Bruce McEwen gave me in the early 1990s. He told me I needed to start with gene activation in GnRH neurosecretory neurons. If not, after several hours of discusssion, he claimed that my model of pheromone-controlled reproduction could never be validated.
Hopefully, that will cause others to ask serious scientists about the validity of claims that link mutations to evolution outside the context of the physiology of pheromone-controlled reproduction in species from microbes to humans.
It may not be clear that species-specific pheromones biophysically constrain the epigenetic drift that is caused by the virus-driven degradation of messenger RNA because both the articles above were published in the Russian language.
The language barrier was also removed in (2015) Cytogenetic approaches for determining ecological stress in aquatic and terrestrial biosystems
Nutrient stress and social stress are the two forms of ecological stress that clearly link energy-dependent changes in electrons to ecosystems via animal models of aquatic and terrestrial biosystems. For comparison see: Mutation-Driven Evolution, which was published on the same day as this refutation of all neo-Darwinian pseudoscientific nonsense and the ridiculous theories touted by “Big Bang” cosmologists: Nutrient-dependent/pheromone-controlled adaptive evolution: a model
“A spatial interactome reveals the protein organization of the algal CO2-concentrating mechanism,” by Luke C.M. Mackinder, Chris Chen, Ryan D. Leib, Weronika Patena, Sean R. Blum, Matthew Rodman, Silvia Ramundo, Christopher M. Adams and Martin C. Jonikas, Cell. DOI: 10.1016/j.cell.2017.08.044
“The eukaryotic CO2-concentrating organelle is liquid-like and exhibits dynamic reorganization,” by Elizabeth S. Freeman Rosenzweig, Bin Xu, Luis Kuhn Cuellar, Antonio Martinez-Sanchez, Miroslava Schaffer, Mike Strauss, Heather N. Cartwright, Pierre Ronceray, Jürgen M. Plitzko, Friedrich Förster, Ned S. Wingreen, Benjamin D. Engel, Luke C. M. Mackinder and Martin C. Jonikas, Cell. DOI: 10.1016/j.cell.2017.08.008
Reported as: Study provides insights into how algae siphon carbon dioxide from the air
Aquatic algae and a handful of other plants have developed carbon-concentrating mechanisms that boost the rate of photosynthesis, the process by which plants turn carbon dioxide and sunlight into sugars for growth. All plants use an enzyme called Rubisco to “fix” carbon dioxide into sugar that can be used or stored by the plant.
Any report of the development of any molecular mechanism that fails to mention that all molecular mechanisms are energy-dependent is probably an attempt to obfuscate the fact that the virus-driven theft of quantized energy has been linked to all pathology by serious scientists and by journalists like John Hewitt.
See also: Cytosis: A Cell Biology Board Game
A board game taking place inside a human cell! Players compete to build enzymes, hormones and receptors and fend off attacking Viruses!