MicroRNAs light up life
(click to enlarge)
Summary: Every aspect of cell type differentiation or mutation-driven pathology occurs downstream from the de novo creation of energy-dependent microRNAs. That fact should be considered in all aspects of top-down causation, which must link the sun’s energy to behavior via the physiology of reproduction and chromosomal inheritance.
On a relational theory of biological systems: a natural model for complex biological behavior (5/29/17)
In this paper, we develop a natural (empirical) relational theory for describing and modeling complex biological phenomena. We have as stepping stone the assertion: function implies structure. The theory is built upon a graph’s theory structure in which a diffusion model of information takes place, and where dynamics can be investigated in order to generate steady quantifiers. In this context, we improve a seminal work by adding a free context biological importance measure given by the Shannon’s Entropy. We also introduce the concept of biological loci. Such concept stands for closely related biological agents which plays a role as an agent by itself. Our results allow us to synthesize a natural model for complex biological behavior that takes into account: system’s update, irreducibility, and exploit of the dynamical behavior mounted over a diffusion model. The model deals in final terms to its natural capacity to model plasticity and environmental changes, which has an intrinsic relationship with Shannon’s Entropy and the sort of dynamics that biological systems can display.
It’s too late for any more of this pseudoscientific nonsense about entropy and increasing organismal complexity, which is energy-dependent and biophysically constrained by the physiology of pheromone-controlled reproduction.
See also: Evolution Not Only About Natural Selection but Also Improvisation, Says Israeli Scientist
Evolution, he argues, is not limited to families of plants and animals, but also occurs inside individual living things – whether they are, say, cells, plants, horses or people.
It is too late for people like him to redefine “evolution” in the context of a theory of adaptive improvisation at the level of links from energy-dependent changes in angstroms to ecosystems. All biologically informed researchers have followed the lead of the late Eshel Ben-Jacob, who realized that natural selection for energy-dependent codon optimality links what organisms eat to the physiology of their pheromone-controlled reproduction. All serious scientists have known that for more than two decades.
To start from cell type differentiation in bacteria, see: Seeking the foundations of cognition in bacteria: From Schrödinger’s negative entropy to latent information (2006)
…it is widely accepted that there is no need for some unknown laws of physics to explain cellular ontogenetic development. We take a different view and in Schrödinger’s foot steps suggest that yet unknown physics principles of self-organization in open systems are missing for understanding how to assemble the cell’s component into an information-based functioning “machine”.
If your ridiculous theory does not explain how the virus-driven degradation of messenger RNA is biophysically constrained by the physiology of nutrient-dependent pheromone-controlled reproduction in species from microbes to humans, you must start learning what serious scientists have learned during the past century.
Simply put, the last universal common ancestor had the ability to find food. That fact attests to the glory of all Creation, which starts with the Creation of sunlight. The claims of some creationists can be placed into the context of a light-activated endogenous substrate in all cell types that links energy as information to endogenous RNA-interference and all biophysically constrained biodiversity via the pheromone-controlled physiology of reproduction.
Theorists can continue to claim whatever they wish. But none of their claims make sense if they cannot link energy to healthy longevity via the physiology of reproduction and also link the virus-driven degradation of messenger RNA from mutations to all pathology.
Serious scientists have done that. See: Scientists investigate how the sense of smell works in bacteria
…the signaling and inactive states differ only very slightly at the nitrate-binding site – by 0.5-1 angstroms, which is approximately one fifth of the size of the ion itself (1 angstrom is 10-10 meters). However, when this ion binds to the sensor, it causes huge changes in the protein: The helices of different monomers begin to move in different directions, like pistons. These “pistons” transmit the small change of 0.5-1 angstroms through the membrane, and their outer ends shift by approximately 2.5 angstroms in different directions. Inside the cell, in the HAMP domain, these shifts are converted into the rotation of two parts of NarQ relative to each other. Ultimately, the positions of the output helices change by as much as 7 angstroms, thus completing the signal transmission.
Disease Awareness Months Work, Even If You Don’t Wear The Ribbon
For the people living with an illness that may lack effective treatments, much less a cure, even small increases in awareness are valuable. And that’s true whether or not anybody remembers what disease they’re supposed to be thinking about this month.
Think about this. Serious scientists have published more than 61,000 papers that link nutrient energy-dependent microRNAs to healthy longevity and virus-driven energy theft from the degradation of messenger RNA to mutations and all pathology. A PubMed search for “microRNA” and the name of the pathology you would like to cure will show you that the cure is always energy-dependent biophysically constrained viral latency.
autism
Myasthenia gravis
Congenital Cytomegalovirus
See also: Items 1 – 20 of 136 from today’s alert notice
5.
Identification of circulating microRNA signatures as potential noninvasive biomarkers for prediction and prognosis of lymph node metastasis in gastric cancer.
Jiang X, Wang W, Yang Y, Du L, Yang X, Wang L, Zheng G, Duan W, Wang R, Zhang X, Wang L, Chen X, Wang C.
Oncotarget . 2017 May 10. doi: 10.18632/oncotarget.17789. [Epub ahead of print]
PMID: 28570996 [PubMed – as supplied by publisher]
10.
The putative tumor suppressor microRNA-30a-5p modulates clear cell renal cell carcinoma aggressiveness through repression of ZEB2.
Chen Z, Zhang J, Zhang Z, Feng Z, Wei J, Lu J, Fang Y, Liang Y, Cen J, Pan Y, Huang Y, Zhou F, Chen W, Luo J.
Cell Death Dis . 2017 Jun 1;8(6):e2859. doi: 10.1038/cddis.2017.252.
PMID: 28569782 [PubMed – in process]
11.
MicroRNA-195 prevents dendritic degeneration and neuron death in rats following chronic brain hypoperfusion.
Chen X, Jiang XM, Zhao LJ, Sun LL, Yan ML, Tian Y, Zhang S, Duan MJ, Zhao HM, Li WR, Hao YY, Wang LB, Xiong QJ, Ai J.
Cell Death Dis . 2017 Jun 1;8(6):e2850. doi: 10.1038/cddis.2017.243.
PMID: 28569780 [PubMed – in process]
19.
Exosomes derived from human umbilical cord mesenchymal stem cells protect against cisplatin-induced ovarian granulosa cell stress and apoptosis in vitro.
Sun L, Li D, Song K, Wei J, Yao S, Li Z, Su X, Ju X, Chao L, Deng X, Kong B, Li L.
Sci Rep . 2017 May 31;7(1):2552. doi: 10.1038/s41598-017-02786-x.
PMID: 28566720 [PubMed – in process]
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4 MIN READ
0
Energy-dependent purifying selection / autophagy (2)
2 MIN READ
0
Energy-dependent purifying selection / autophagy (3)
2 MIN READ
0
Energy-dependent purifying selection / autophagy (4)
2 MIN READ
0
Energy-dependent purifying selection / autophagy (5)
2 MIN READ
0
Energy-dependent purifying selection / autophagy (6)
3 MIN READ
0
Energy-dependent purifying selection / autophagy
2 MIN READ
0
Energy-dependent maternal-to-zygotic transition
6 MIN READ
1
Epigenetically effected energy-dependent fluorescence
5 MIN READ
0
Epigenetics and autophagy vs mutations and evolution (3)
< 1 MIN READ
0
Top-down adaptation vs bottom-up evolution
6 MIN READ
0
The natural success of RNAi and failed treatment
7 MIN READ
0
Did evolution autophosphorylate your kinases?
5 MIN READ
1
Nutrient-dependent pheromone-controlled autophagy (2)
6 MIN READ
0
Nutrient-dependent pheromone-controlled autophagy
3 MIN READ
0
Life is energy-dependent task management
3 MIN READ
0
Hypothesis free pseudoscience vs facts (1)
5 MIN READ
0
Chromatin: The structure of DNA (3)
4 MIN READ
0
Hydrogen-atom energy in DNA base pairs
6 MIN READ
0
The Aquatic Ape / Waterside Ape divergence
6 MIN READ
0
Light energy-induced base pair changes (2)
4 MIN READ
0
Light energy-induced base pair changes (1)
6 MIN READ
0
Displays of ecological adaptation (2)
3 MIN READ
0
Unconstrained mutations, Zika virus, Kallmann’s syndrome
4 MIN READ
0
Linking RNA structure to function
3 MIN READ
0
How did the innate immune system evolve?
4 MIN READ
0
The Aquatic Ape: New evidence?
4 MIN READ
0
Protecting 4 billion people from virus-driven entropy
< 1 MIN READ
0
Energy-dependent cellular communication
3 MIN READ
0
Lawless evolution: No physics
4 MIN READ
0
Conserved biophotonic emissions
7 MIN READ
2
Antithetical conclusions (7)
3 MIN READ
0
Non-random pheromone-controlled cell type differentiation
3 MIN READ
0
RNAi: From magic bullet to billion dollar baby
4 MIN READ
0
Energy-dependent natural fluorescence and bioluminescence
2 MIN READ
0
GC-rich neo-Darwinian train wreck
5 MIN READ
0
From angstroms to ecosystems
7 MIN READ
0
Food supplement or licensed immunostimulant?
6 MIN READ
0
The end of neo-Darwinism
5 MIN READ
0
Biophotonics, glycobiology, quantized biodiversity
4 MIN READ
0
The Origin of Information (2)
6 MIN READ
0
The tipping point? 50,000 publications (5)
3 MIN READ
0
Did “Nature” kill Steve Jobs? (3)
10 MIN READ
0
Invisible dark matter
< 1 MIN READ
0
Funding the Human Genome Project-Write
2 MIN READ
0
Did “Nature” kill Steve Jobs? (2)
6 MIN READ
0
Did “Nature” kill Steve Jobs?
3 MIN READ
0
Placing boundaries where none exist
< 1 MIN READ
0
Virus-driven downsizing of the human brain
2 MIN READ
0
Innate immunity and multiplexing
7 MIN READ
0
RNA methylation (2)
7 MIN READ
0
Masters of deception about nature (2)
7 MIN READ
0
The Mind’s Eyes (revisited)
10 MIN READ
0
Cracking the Olfactory Code?
5 MIN READ
0
RNA methylation, behavior, and disease
6 MIN READ
0
Energy-dependent RNA methylation (9)
2 MIN READ
0
Energy-dependent RNA methylation (7)
7 MIN READ
0
Energy-dependent RNA methylation (6)
9 MIN READ
0
Energy-dependent RNA methylation (5)
3 MIN READ
0
Energy-dependent RNA methylation (1)
6 MIN READ
0
War Games: False Flag Terrorism
5 MIN READ
0
The tipping point? 50,000 publications (3)
6 MIN READ
0
Energy-dependent creation and entropy
4 MIN READ
0
RNA-mediated physics, chemistry, and molecular epigenetics (4)
5 MIN READ
0
RNA-mediated physics, chemistry, and molecular epigenetics (3)
5 MIN READ
0
RNA-mediated physics, chemistry, and molecular epigenetics (2)
7 MIN READ
0
RNA splicing, genetic variation, and disease
2 MIN READ
0
Wasted Templeton Funding (2)
2 MIN READ
0
A bumper crop of virus-infected weeds and people
2 MIN READ
0
Molecular Diagnostics: What is unprotected life? (5)
5 MIN READ
0
Molecular Diagnostics: What is unprotected life?
2 MIN READ
0
YEC compared to Perry Marshall’s opinions
4 MIN READ
0
Creating nutrient-dependent life with enough genes to survive
3 MIN READ
0
Confusing effects and affects of visual input
2 MIN READ
0
Do not miss the misrepresentations
2 MIN READ
0
Energy dependent RNA-mediated immunity (5)
4 MIN READ
0
Energy dependent RNA-mediated immunity (2)
10 MIN READ
0
Soil bacteria, bulls, cows, microRNAs, and mammary glands
3 MIN READ
0
Bringing RNA back to epigenetics (20 years later)
11 MIN READ
0
Effects on invertebrate GnRH and affects on primate behavior
6 MIN READ
0
Creating gravity, nucleic acids, receptors, and supercoiled DNA (2)
9 MIN READ
0
Bacteria see the light and they adapt
7 MIN READ
0
The Light and Darkness of “Evolution 2.0”
11 MIN READ
0
Despicable fools?
4 MIN READ
0
Ricki Lewis’ Time Machine
5 MIN READ
0
Hydrogen-atom transfer in DNA base pairs (5)
10 MIN READ
0
Center stage RNA-mediated events (since 1996)
3 MIN READ
0
A failed theory of cancer: two more decades of pseudoscience
5 MIN READ
0
Ecological law, cooperation, and DNA repair
4 MIN READ
0
Genes, orchid odors, and pheromones from blonds
5 MIN READ
0
Finding peace and π in the light of H bond energy (2)
8 MIN READ
0
Finding peace and π in the light of H bond energy
5 MIN READ
0
Epigenetic (re)programming of behavior (2)
6 MIN READ
0
Neo-Darwinian sink testing
2 MIN READ
0
Did Dobzhansky see the UV light of creation?
10 MIN READ
0
Researchers rename, reshuffle, and reveal their ignorance
3 MIN READ
0
Hydrogen-Atom Transfer in DNA Base Pairs (3)
3 MIN READ
0
Ecological adaptations you cannot live without
6 MIN READ
0
RNA-mediated theory killers (2)
8 MIN READ
0
A million dollar paradox?
2 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair (4)
6 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair (3)
8 MIN READ
0
Innovative Neurotechnologies Link Sunlight to Precision Medicine
4 MIN READ
0
Sulfated steroids and RNA-mediated identity codes
< 1 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair
2 MIN READ
0
Positive feedback loops and epigenetic traps
2 MIN READ
0
Stress-perturbed mitochondrial dysfunction
4 MIN READ
0
Let there be anti-entropic light (3)
6 MIN READ
0
Neuroplasticity
4 MIN READ
0
Sensationalizing no new mechanism
2 MIN READ
0
Too complex for the Complex Biological Systems Alliance
4 MIN READ
0
Rediscovering quantum behavior
2 MIN READ
0
RNA central and RNA-mediated.com
6 MIN READ
0
Skip the politics; embrace the facts
5 MIN READ
0
700 million years of evolution?
5 MIN READ
0
RNA-mediated retrotransposon-mediated biodiversity
3 MIN READ
0
Mystery machine vs medical intelligence
2 MIN READ
0
Epigenetic inheritance of stress-perturbed protein folding
2 MIN READ
0
Preventing genomic entropy
4 MIN READ
0
Energy and evolution: another opinion?
2 MIN READ
0
Bird watchers and RNAs in cancers
2 MIN READ
0
Supercoiled DNA constrains virus-driven genomic entropy
2 MIN READ
0
Let there be anti-entropic light (2)
4 MIN READ
0
Foundamentals of theory
4 MIN READ
0
Is mainstream science in “Science” pseudoscience?
5 MIN READ
0
Theorists have not seen the light
4 MIN READ
0
A 5-10K comparison of design principles to evolution
3 MIN READ
0
Genome sequencing, cadherins, and quantum consciousness
6 MIN READ
0
“New” quantum biology. Pirating the old
3 MIN READ
0
Cell types, SNVs, CNVs, and chromosomes
3 MIN READ
0
Is life the balance between quantum and classical physics?
3 MIN READ
0
Anti-entropic containment of energy: symbiosis 1.0
5 MIN READ
0
The “great filter” is an epigenetic trap
4 MIN READ
0
Information and communication
2 MIN READ
0
Eibi Nevo gets it wrong
3 MIN READ
0
Protosuns, prebiotic molecules, proteins, and people
4 MIN READ
0
The stability of organized genomes (3)
3 MIN READ
0
The stability of organized genomes
5 MIN READ
0
Viruses, amino acids, and somatic cell types (3)
9 MIN READ
0
Viruses, amino acids, and somatic cell types (2)
5 MIN READ
0
RNA-mediated morphological AND behavioral phenotypes
2 MIN READ
0
Becoming biologically informed (3)
3 MIN READ
0
Easy editing: Reinventing our RNA world
3 MIN READ
0
RNA-mediated gene duplication, fixation, and ecological adaptation
6 MIN READ
0
MicroRNA controlled growth and brain development
7 MIN READ
0
MicroRNA – controlled ecological adaptations
5 MIN READ
0
“New” epigenetic mechanism for lifelong learning?
3 MIN READ
0
microRNAs, glycosylation, and genomes
4 MIN READ
0
Epigenetic regulation of aging by glycine and GnRH
5 MIN READ
0
Pattern recognition: biogeochemical structure and function
5 MIN READ
0
Viruses and the human-like microbiome
3 MIN READ
0
Informing the biologically uninformed
< 1 MIN READ
0
I forgot. How do mutations cause evolution?
4 MIN READ
0
Ignoring systems complexity (it’s too complicated)
3 MIN READ
0
Computing via phosphorylation and fixation
3 MIN READ
0
A special issue on nutritional epigenetics
5 MIN READ
0
Epigenetics: microRNAs effect an integrative pathway
4 MIN READ
0
Linking the origin of birds to dinosaurs
< 1 MIN READ
0
Two types of microRNA are not double agents
2 MIN READ
0
Quantum Superpositions: let there be light
4 MIN READ
0
Are viruses microRNAs? (2)
5 MIN READ
0
Are viruses microRNAs?
3 MIN READ
0
Sneaking up from behind
4 MIN READ
0
In theory, or supported by experimental evidence?
5 MIN READ
0
No excuses: Creation and the meaning of organismal complexity
7 MIN READ
0
RNA-mediated cell type differentiation and behavior
3 MIN READ
0
Physics denied; pseudoscientific nonsense accepted
2 MIN READ
0
Stop evolutionary theorists. Kill cancers
3 MIN READ
0
RNA-directed DNA methylation and RNA-mediated events
5 MIN READ
1
Miracles are not miracles to evolutionary theorists
2 MIN READ
0
Seemingly futile cycles are not thermodynamically futile
3 MIN READ
0
“Kardashians” in science
< 1 MIN READ
0
Can epigenetic inheritance occur without concurrent changes in morphology AND behavior?
3 MIN READ
0
Watching and waiting for more retractions
2 MIN READ
0
RNA-mediated events found everywhere
2 MIN READ
0
Nutrient-dependent erythropoiesis and anemia
6 MIN READ
0
Evolutionary heritage or ecological adaptation? Racism versus reality
4 MIN READ
0
microRNAs and species relationships
3 MIN READ
0
Not focused and self-aggrandizing
2 MIN READ
0
Targeting a cancer gene
2 MIN READ
0
Pheromone-controlled thermodynamics and cancer
2 MIN READ
0